Department of Chemical Biology 

College of Chemistry & Chemical Engineering

Xiamen University

China 361005                                        

Fax: +86-218-9959                              

Email: alina1222@xmu.edu.cn

Education

Professional Experience

Research interests

• Exploitation novel high-throughput single-cell method for studying toxin/antitoxin systems

• Sensitive and selective single cell (bacteria, virus, etc) detection

• Investigation on protein-protein interaction through bacteria two-hybrid system

• Bioanalysis of antibiotic resistance

• Chemical biology and functional proteomics research

Publications

1. Wu LN, Luan T , Yang XT , Wang S , Zheng Y , Huang TX, Zhu SB, and Yan XM*, Trace Detection of Specific Viable Bacteria Using Tetracysteine-Tagged Bacteriophages, Anal. Chem., 2014, 86(1), 907-912.

2. Wu LN，Huang TT，Yang LL，Pan JB，Zhu SB，Yan XM*. Sensitive and Selective Bacterial Detection Using Yetracysteine-tagged Phages in Conjunction with Biarsenical Dye. Angew. Chem. Int. Ed.  2011，50，5873 - 5877.

3. Wu LN, Lin XM, Peng XX*, From Proteome to Genome for Functional Characterization of pH-Dependent Outer Membrane Proteins in Escherichia coli, J. Proteome Res. 2009, 8, 1059-1070.

4. Wu LN, Lin XM, Wang FP, Ye DZ, Xiao X, Wang SY, Peng XX*, OmpW and OmpV Are Required for NaCl Regulation in Photobacterium damsela, J. Proteome Res. 2006, 5, 2250-2257.

5. Yang LL, Huang TX, Zhu SB, Zhou YX, Jiang YB, Wang S, Chen YQ, Wu LN, Yan XM*, High-throughput Single-cell Analysis of Low Copy Number β-galactosidase by a Laboratory-built High-sensitivity Flow Cytometer, Biosens Bioelectron., 2013, 48C, 49-55.

6. Yang LL, Zhou YX, Zhu SB, Huang TX, Wu LN, Yan XM*, Detection and Quantification of Bacterial Autofluorescence at the Single-Cell Level by a Laboratory-Built High-Sensitivity Flow Cytometer, Anal. Chem., 2012, 84(3), 1526-1532.

7. Yang LL, Wu LN, Zhu SB, Long Y, Hang W, Yan XM*, Rapid, absolute, and simultaneous quantification of specific pathogenic strain and total bacterial cells using an ultrasensitive dual-color flow Cytometer, Anal. Chem. 2010, 82, 1109-1116.

8. Yang LL, Zhu SB, Hang W, Wu LN, Yan XM*, Development of an ultrasensitive dual-channel flow cytometer for the individual analysis of nanosized particles and biomolecules, Anal. Chem. 2009, 81, 2555-2563.

9. Lin XM, Wu LN, Li H, Wang SY, Peng XX*, Downregulation of Tsx and OmpW and upregulation of OmpX are required for iron homeostasis in Escherichia coli, J. Proteome Res. 2008, 7, 1235-1243.

10. Huang CZ, Lin XM, Wu LN, Zhang DF, Liu D, Wang SY, Peng XX*, Systematic identification of the sub-proteome of Escherichia coli cell envelope reveals the interaction network of membrane proteins and membrane-associated peripheral proteins, J. Proteome Res. 2006, 5, 3268-3276.

11. Peng XX*, Xu CX, Ren HX, Lin XM, Wu LN, Wang SY, Proteomic analysis of the Sarcosine-insoluble outer membrane fraction of Pseudomonas aeruginosa responding to ampicilin, kanamycin, and tetracycline resistance, J. Proteome Res. 2005, 4, 2257-2265.

12. Xu CX, Wang SY，Ren HX, Lin XM, Wu LN, Peng XX*,  Proteomic analysis on the expression of outer membrane proteins of Vibrio alginolyticus at different sodium concentrations, Proteomics 2005, 5, 3142-3152.

Patents

1. Peng XX, Wu LN. The application and preparation method for ompW of Photobacterium damsela. China Invention Patent, Patent No. ZL 2005 1 0100211.3.

2. Peng XX, Wu LN. The application and preparation method for ompV of Photobacterium damsela. China Invention Patent, Patent No. ZL 2005 1 0100213.2.

3. Peng XX, Wu LN, Xu CX, Wang SY. The application and preparation method for ompW of Vibrio alginolyticus. China Invention Patent, Patent No.200510053225.4.

4. Peng XX, Li H, Lin XM, Wu LN. Escherichia coli TolC antibody targeting effect improving drug-resistant bacteria sensitivity to antibiotic technology. China Invention Patent, Patent No. 200710029101.1.

5. Peng XX; Li H; Zhang DF; Zhang BW; Wu LN. Anti-Escherichia coli TolC segment antibody, its preparation and application to prepare drugs for inhibiting bacterial drug resistance. China Invention Patent, Patent No. 201110002263.2.