79. 高恺旻, 颜晓梅*. 生物制药领域蛋白质团聚检测技术的研究进展,《分析化学》, 2018, 46(10), 1507-1517.

78. Wenqiang Zhang, Ye Tian, Xiuxiu Hu, Shengbin He, Qian Niu, Chaoxiang Chen, Shaobin Zhu, and Xiaomei Yan*, Light-Scattering Sizing of Single Submicron Particles by High-Sensitivity Flow Cytometry, Anal. Chem. 2018. (DOI: 10.1021/acs.analchem.8b03135)

77. Gao Min1, Lian Hong1, Yu Longjiao, Gong Manfei, Ma Ling, Zhou Yingxing, Yu Muxin, Yan Xiaomei*, Rolling circle amplification integrated with suspension bead array for ultrasensitive multiplex immunodetection of tumor markers, Anal. Chim. Acta, 2018. (DOI: 10.1016/j.aca.2018.10.001)

76. Ye Tian, Ling Ma, Manfei Gong, Guoqiang Su*, Shaobin Zhu, Wenqiang Zhang, Shuo Wang, Zhibin Li, Chaoxiang Chen, Lihong Li, Lina Wu, Xiaomei Yan*, Protein Profiling and Sizing of Extracellular Vesicles from Colorectal Cancer Patients via Flow Cytometry, ACS Nano, 2018, 12, 671-680. 

75. Yan, Y; Meng, LY; Zhang, WQ; Zheng, Y; Wang, S; Ren, B; Yang, ZL*; Yan, XM*. High-Throughput Single-Particle Analysis of Metal-Enhanced Fluorescence in Free Solution Using Ag@SiO2 Core-Shell Nanoparticles, ACS Sensors, 2017, 2017, 2, 1369-1376.

74. Wang, S; Li, LH; Jin, SH; Li, WF; Hang, W; Yan, XM*, Rapid and Quantitative Measurement of Single Quantum Dots in a Sheath Flow Cuvette, Anal. Chem. 2017, 89, 9857-9863.

73. Chen, CX; Zhu, SB; Wang, S; Zhang, WQ; Cheng, Y; Yan, XM*. Multiparameter Quantification of Liposomal Nanomedicines at the Single-particle Level by High Sensitivity Flow Cytometry, ACS Appl. Mater. Interfaces, 2017, 9, 13913-13919.

72. Wu, LN;† Wang, X;† Zhang, JQ; Luan, T; Bouveret, E.; Yan, XM*. Flow cytometric single-cell analysis enables quantitative in vivo detection of protein-protein interactions via relative reporter protein expression measurement, Anal. Chem. 2017, 89, 2782-2789. (†: co-first authors)

71. He, SB; Hong, XY, Huang, TX; Zhang, WQ; Zhou, YX; Wu, LN; Yan, XM*. Rapid quantification of live/dead lactic acid bacteria in probiotic products using high-sensitivity flow cytometry, Methods Appl. Fluoresc. 2017, 5, 024002.

70. Wang, PY; Zeng, WJ; Liu, J; Wu, YL; Ma, YH; Zeng, ZP; Pang, JY; Zhang, XK; Yan, XM; Sze Tsai Wong, A; Zeng, JZ*. TRC4, an improved triptolide derivative, specifically targets to truncated form of retinoid X receptor-alpha in cancer cells. Biochem. Pharmacol 2017, 124, 19-28.

69. Ma, L;† Zhu, SB;† Tian, Y; Zhang, WQ; Wang, S; Chen, CX; Wu, LN; Yan, XM*. A label-free analysis of single viruses with a resolution comparable to that of electron microscopy and the throughput of flow cytometry, Angew. Chem. Int. Ed., 2016, 55, 10239 –10243. (hot paper, †: co-first authors)

68. Wu, LN; Song, YY; Luan, T; Ma, L; Su, LQ; Wang S; Yan XM*. Specific detection of live Escherichia coli O157:H7 using tetracysteine-tagged PP01 bacteriophage, Biosens. Bioelectron. 2016, 86, 102-108.

67. Huang, TX;† Zheng, Y;† Yan, Y; Yang, LL; Yao, YH; Zheng, JX; Wu, LN; Wang, X; Chen, YQ; Xing, JC; Yan, XM*. Probing minority population of antibiotic-resistant bacteria, Biosens. Bioelectron. 2016, 80, 323-330. (†, co-first authors)

66. Wu, LN; Wang, S; Song, YY; Wang, X; Yan, XM*. Applications and challenges for single-bacteria analysis by flow cytometry, Sci. China Chem. 2016, 59, 30-39.

65. 韩锦艳,许静怡,张翔,周颖星,陈超翔,颜晓梅*. 线粒体荧光标记的单颗粒水平高通量评估方法,《分析化学》, 2016, 44, 1171-1177.

64. Zhu, L;† Xiong, P;† Mao, ZY; Wang, YH; Yan, XM; Lu, X; Xu, HC*. Electrocatalytic generation of amidyl radicals for olefin hydroamidation: use of solvent effects to enable anilide oxidation, Angew. Chem. Int. Ed. 2016, 55, 2226-2229. (†, co-first authors)

63. Chen, CX; Zhang, X; Zhang, SY; Zhu, SB; Xu, JY, Zheng, Y; Han, JY, Zeng, JZ; Yan, XM*. Quantification of protein copy number in single mitochondria: the Bcl-2 family proteins, Biosens. Bioelectron. 2015, 74, 476-482.

62. Yu, MX; Wu, LN; Huang, TX; Wang, S; Yan, XM*. Rapid detection and enumeration of total bacteria in drinking water and tea beverages by a laboratory-built high-sensitivity flow cytometer, Anal. Methods. 2015, 7, 3072-3079.

61. 许静怡,陈超翔,韩锦艳,杭纬,颜晓梅*. 线粒体蛋白质组学研究进展,《分析化学》, 2015, 43, 1257-1264.

60. Shen, W; Lin, X; Jiang, CY; Li, CY; Lin, HX; Huang, JT; Wang, S; Liu, GK; Yan, XM; Zhong, QL; Ren, B*, Reliable Quantitative SERS Analysis Facilitated by Core-Shell Nanoparticles with Embedded Internal Standards, Angew. Chem. Int. Ed. 2015, 54, 7308 –7312.

59. Zhang, Z*; Deng, CQ; Meng, LS; Zheng, Y; Yan, XM. A rhodamine hydrazide-based fluorescent probe for sensitive and selective detection of hypochlorous acid and its application in living cells, Anal. Methods. 2015, 7, 107-114.

58. Zhu, SB; Ma, L; Wang, S; Chen, CX; Zhang, WQ; Yang, LL; Hang, W; Nolan, J. P.; Wu, LN; Yan, XM*. Light-scattering detection below the level of single fluorescent molecules for high-resolution characterization of functional nanoparticles. ACS Nano 2014, 8, 10998-11006.

57. Zhang, X; Zhang, SY; Zhu, SB; Chen, S; Han, JY; Gao, KM; Zeng, JZ; Yan, XM*. Rapid identification of mitochondria-targeting anticancer compounds by an in vitro strategy, Anal. Chem. 2014, 86, 5232−5237.

56. Wu, LN; Luan, T; Yang, XT; Wang, S; Zheng, Y; Huang, TX; Zhu, SB; Yan, XM*. Trace detection of specific viable bacteria using tetracysteine-tagged bacteriophages, Anal. Chem. 2014, 86, 907-912.

55. Yang, CW; Chen, S; Zhou, M; Li, Y; Li, YF; Zhang, ZX; Liu, Z; Ba, Q; Li, JQ; Wang, H; Yan, XM*; Ma, DW*; Wang, RX*. Development of 3-Phenyl-N-(2-(3-phenylureido) ethyl)-thiophene-2-sulfonamide compounds as inhibitors of antiapoptotic Bcl-2 family proteins, ChemMedChem, 2014, 9, 1436 - 1452.

54. Xu, F; Zhu, L; Zhu, SB; Yan, XM; Xu, HC*. Electrochemical intramolecular aminooxygenation of unactivated alkenes, Chem. Eur. J. 2014, 20, 12740- 12744.

53. Huang, ZZ; Zhang, SD; Hang, W*; Chen, YD; Zheng, JX; Li, W; Xing, JC; Zhu, EY; Yan, XM. Liquid chromatography-mass spectrometry based serum peptidomic approach for renal clear cell carcinoma diagnosis, J. Pharmaceut. Biomed. Anal. 2014, 100, 175-183.

52. Shao, Q; Zheng, Y; Dong, XM; Tang, K; Yan, XM*; Xing BG*. A covalent reporter of β-lactamase activity for fluorescent imaging and rapid screening of antibiotic-resistant bacteria, Chem. Eur. J., 2013, 19, 10903-10910.

51. Yang, LL;† Huang, TX;† Zhu, SB; Zhou YX; Jiang, YB; Wang, S; Chen, YQ; Wu, LN; Yan XM*. High-throughput single-cell analysis of low copy number β-Galactosidase by a laboratory-built high-sensitivity flow cytometer, Biosens. Bioelectron. 2013, 48, 49-56. (†, co-first authors)

50. Chen, CX; Zhu, SB; Huang, TX; Wang S; Yan, XM*. Analytical techniques for single-liposome characterization. Anal. Methods, 2013, 5, 2150-2157.

49. Yang, L; Wu, SQ; Lin, BJ; Huang, TX; Chen, XP; Yan, XM; Han, SF*. A targetable nanogenerator of nitric oxide for light-triggered cytotoxicity. J. Mater. Chem. B, 2013, 1, 6115.

48. Huang, ZZ; Chen, YJ; Hang, W.*, Gao, Y.; Lin, L.; Li, D. Y.; Xing, JC; Yan, XM. Holistic Metabonomic Profiling of Urine Affords Potential Early Diagnosis for Bladder and Kidney Cancers, Metabolomics, 2013, 9, 119-129.

47. Zhang, SY;† Zhu, SB;† Yang, LL; Zheng, Y; Gao, M; Wang, S; Zeng, J-Z; and Yan, XM*. High-throughput multiparameter analysis of individual mitochondria, Anal. Chem. 2012, 84, 6421-6428. (†, co-first authors)

46. Yang, LL; Zhou, YX; Zhu, SB; Huang, TX; Wu, LN; Yan, XM*. Detection and quantification of bacterial autofluorescence at the single-cell level by a laboratory-built high-sensitivity flow cytometer, Anal. Chem. 2012, 84, 1526-1532.

45. Huang, H; Chen, ZJ; Yan, XM*. Simultaneous determination of serotonin and creatinine in urine by combining two ultrasound-assisted emulsification microextractions with on-column stacking in capillary electrophoresis, J. Sep. Sci. 2012, 35, 436-444.

44. Lin, L; Huang, ZZ; Gao, Y; Chen, YJ; Hang, W.*, Xing, JC; Yan, XM. LC-MS based serum metabolic profiling for genitourinary cancer classification and cancer type-specific biomarker discovery, Proteomics, 2012, 12, 2238-2246.

43. Lu, N.; Liu, JX; Liu, J.; Zhang, CY; Jiang, FQ; Wu, H.; Chen, LQ; Zeng, WJ; Cao, XH; Yan, TD; Wang, GH; Zhou, H.; Lin, BZ; Yan, XM; Zhang, XK; and Zeng, JZ*. Antagonist effect of triptolide on AKT activation by truncated retinoid X receptor-alpha. PLoS One 2012, 7(4): e35722.

42. Gao, Y.; Yang, N.; Yan, XM; Hang, W.*; Xing, JC; Zheng, J.; Zhu, EY; Huang, BL. Early diagnosis of urinary lithiasis via elementary profile of serum samples, Anal. Methods 2012, 4, 693-698.

41. Wu, LN; Huang, TT; Yang, LL; Pan, JB; Zhu, SB; Yan, XM*. Sensitive and selective bacterial detection using tetracysteine-tagged phages in conjunction with biarsenical dye, Angew. Chem. Int. Ed. 2011, 50, 5873-5877.

40. Zhu, SB; Wang, S; Yang, LL; Huang, TX; Yan, XM*. Progress in the development of techniques based on light scattering for single nanoparticle detection, Sci. China Chem., 2011, 54, 1244-1253.

39. Zheng, Y; Lin, L; Hang, W; Yan, XM*; Marrone, B. L.* Analysis of beryllium to biomolecule binding using a metal specific fluorescent probe and competitive Assay, Talanta, 2011, 85, 638-643.

38. Zhang, Z*; Zheng, Y; Hang, W; Yan, XM*; Zhao, YF. Sensitive and selective off-on rhodamine hydrazide fluorescent chemosensor for hypochlorous acid detection and bioimaging, Talanta, 2011, 85, 779-786.

37. Huang, ZZ; Lin, L; Gao, Y; Chen, YJ; Yan, XM; Xing, JC; Hang, W*. Bladder cancer determination via two urinary metabolites: a biomarker pattern approach, Mol. Cell. Proteomics, 2011, 10, 10.1074/mcp.M111.007922-1–007922-10.

36. Lin, L; Huang, ZZ; Gao, Y; Yan, XM; Xing, JC; Hang, W*. LC-MS based serum metabonomic analysis for renal cell carcinoma diagnosis, staging, and biomarker discovery, J. Proteome. Res., 2011, 10, 1396-1405. 

35. Zhu, SB; Yang, LL; Long, Y; Gao, M; Huang, TX; Hang, W; Yan, XM*. Size differentiation and absolute quantification of gold nanoparticles via single particle detection with a laboratory-built high-sensitivity flow Cytometer, J. Am. Chem. Soc. 2010, 132, 12176-12178.

34. Yang, LL; Wu, LN; Zhu, SB; Long, Y; Hang, W; Yan, XM*. Rapid, absolute, and simultaneous quantification of specific pathogenic strain and total bacterial cells using an ultrasensitive dual-color flow Cytometer, Anal. Chem., 2010, 82, 1109-1116.

33. Zhang, ZL; Long, Y; Pan, JB; Yan, XM*. Preparation of fluorescence-encoded microspheres in a core-shell structure for suspension arrays, J. Mater. Chem., 2010, 20, 1179-1185.

32. Long, Y; Zhang, ZL; Yan, XM*; Xing, JC*; Zhang, KY; Huang, JX; Zheng, JX; Li, W. Multiplex immunodetection of tumor markers with a suspension array built upon core-shell structured functional fluorescence-encoded microspheres, Anal. Chim. Acta, 2010, 665, 63-68.

31. Yan, XM; Lin, YM; Huang, RF; Hang, W*; Harrison, W. W. A spectroscopic investigation of the afterglow and recombination process in a microsecond pulsed glow discharge, J. Anal. At. Spectrom., 2010, 25, 534-543.

30. Lin, L; Yu, Q; Yan, XM; Hang, W*; Zheng, JX; Xing, JC; Huang, BL. Direct infusion mass spectrometry or liquid chromatography mass spectrometry for human metabonomics? A serum metabonomic study of kidney cancer, Analyst, 2010, 135, 2970-2978.

29. Xing, JC*; Yan, LJ; Zhang, J*; Lin, L; Gao, Y; Chen, WG; Song, XY; Yan, XM; Hang, W*; Huang, BL. A comparative study of elution gradients in UPLC-TOF-MS-based metabonomics research, Chromatographia, 2010, 72, 807-813.

28. Yang, LL; Zhu, SB; Hang, W; Wu, LN; Yan, XM*. Development of an ultrasensitive dual-channel flow cytometer for the individual analysis of nanosized particles and biomolecules, Anal. Chem., 2009, 81, 2555-2563. 

27. Ding, J; Lin, L; Hang, W; Yan, XM*. Beryllium uptake and related biological effects studied in THP-1 differentiated macrophages, Metallomics, 2009, 1, 471-478. 

26. Chen, ZJ; Yan, XM*. Simultaneous determination of melamine and 5-hydroxymethylfurfural in milk by capillary electrophoresis with diode array detection, J. Agric. Food Chem., 2009, 57, 8742-8747.

25. Zhang, J*; Yan, LJ; Chen, WG; Lin, L; Song, XY; Yan, XM; Hang, W*; Huang, BL. Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system, Anal. Chim. Acta, 2009, 650, 16-22. 

24. Chen, LZ; Lin, L; Yu, Q; Yan, XM; Hang, W*; He, J; Huang, BL. Semiquantitative multielemental analysis of biological samples by a laser ionization orthogonal time-of-flight mass spectrometer, J. Am. Soc. Mass Spectrom., 2009, 20, 1355-1358. 

23. Yang, LL; Zhu, SB; Hang, W; Yan, XM*. Development of a single-molecule flow analyzer, Chem. J. Chinese U., 2008, 29, 1549-1551.

22. Zhang, J*; Yan, LJ; Lin, L; Chen, WG; Song, XY; Yan, XM; Hang, W*; Huang, BL. Metabonomics research of diabetic mellitus and diabetic nephropathy based on UPLC-oaTOF-MS system, Chem. J. Chinese U., 2008, 29, 2171-2173.

21. He, J; Zhong, WW; Tang, AJ; Yan, XM; Lewis, C.; Majidi, V.; Hang, W. A fluorescence detection scheme for ultra large molecules after gas phase separation, Talanta, 2007, 71, 2126-2128.

20. Yan, XM*; Zhong, WW; Tang, AJ; Schielke, E. G.; Hang W, Nolan J. P. Multiplexed flow cytometric immunoassay for influenza virus detection and differentiation, Anal. Chem., 2005, 77, 7673-7678.

19. Yan, XM*; Habbersett R. C.; Yoshida, T. M.; Nolan, J. P.; Jett, J. H.; Marrone, B. L. Probing the kinetics of SYTOX Orange stain binding to double-stranded DNA with implications for DNA analysis, Anal. Chem., 2005, 77, 3554-3562.

18. Yan, XM*; Tang, AJ; Schielke, E.G.; Hang, W; Nolan, J. P. On the development of a microsphere-based multiplexed immunoassay for influenza virus typing and subtyping by flow cytometry, Options for the control of influenza V, International Congress Series, 2004, 1263, 342-345.

17. Yan, XM*; Schielke, E.G.; Grace, K.M.; Hassell, C.; Marrone, B. L.; Nolan, J. P.* Microsphere-based duplexed immunoassay for influenza virus typing by flow cytometry, J. Immunol. Methods, 2004, 284, 27-38. 

16. Ferris, M. M.; Yan, XM; Habbersett, R. C.; Shou, YL; Lemanski, C. L.; Jett, J. H.; Yoshida, T. M.; Marrone, B. L. Performance assessment of DNA fragment sizing by high sensitivity flow cytometry and pulsed field gel electrophoresis, J. Clin. Microbiol., 2004, 42, 1965-1976.

15. Yan, XM; Hang, W; Majidi, V.; Marrone, B. L.; Yoshida, T. M. Evaluation of different nucleic acid stains for sensitive dsDNA analysis with capillary electrophoresis separation, J. Chromatogr. A., 2002, 943, 275-285.  

14. Yan, XM; Ingeneri, K.; Hang, W; Harrison, W. W. Factors influencing signal profiles in microsecond pulsed glow discharge atomic emission spectrometry, J. Anal. At. Spectrom., 2001, 16, 819-824.

13. Yan, XM; Habbersett, R. C.; Cordek, J. M.; Nolan, J. P.; Yoshida, T. M.; Jett, J. H.; Marrone, B. L. Development of a mechanism-based, DNA staining protocol using SYTOX Orange nucleic acid stain and DNA fragment sizing flow cytometry, Anal. Biochem., 2000, 286, 138-148.

12. Yan, XM; Grace, W. K.; Yoshida, T. M.; Habbersett, R. C.; Velapan, N.; Jett, J. H.; Keller, R. A.; Marrone, B. L. Characteristics of different nucleic acid staining dyes for DNA fragment sizing by flow cytometry, Anal. Chem., 1999, 71, 5470-5480. 

11. Hang, W; Yan, XM; Wayne, D. M.*; Olivares, J. A.; Harrison, W. W.; Majidi, V. Glow discharge source interfacing to mass analyzers: Theoretical and practical considerations, Anal. Chem., 1999, 71, 3231-3237.

10. Hang, W; Yan, XM; Wayne, D. M.; Olivares, J. A.; Harrison, W. W.; Majidi, V.* Selective removal of matrix ion peaks in plasma source time-of-flight mass spectrometry: ion deflection and detector gating, J. Anal. At. Spectrom., 1999, 14, 1523-1526.

9. Duan, YX; Danen, R. E.; Yan, XM; Steiner, R.; Cuadrado, J.; Wayne, D.; Majidi, V.; Olivares, J. A*. Characterization of an improved thermal ionization cavity source for mass spectrometry, J. Am. Soc. Mass Spectrom., 1999, 10, 1008-1015.

8. Yan, XM; Hang, W; Smith, B. W.; Winefordner, J. D.; Harrison, W. W.* Primary studied of microsecond pulsed glow discharge as an emission sources by using conventional hollow cathode lamp, J. Anal. At. Spectrom., 1998, 13, 1033-1038.

7. Harrison, W. W.*; Hang, W; Yan, XM; Ingeneri, K.; Schilling, C. Temporal considerations with a pulsed glow discharge”, J. Anal. At. Spectrom., 1997, 12, 891-896.

6. Yan, XM*; Huang, BL; Tanaka, T.; Kawaguchi, H. Langmuir probe potential measurements for reduced pressure inductively coupled plasma mass spectrometry, J. Anal. At. Spectrom., 1997, 12, 697-701.

5. Yan, XM; Tanaka, T.; Kawaguchi, H.* Electrothermal vaporization for the determination of halogens by reduced pressure inductively coupled plasma mass spectrometry, Spectrochim. Acta B, 1996, 51, 1345-1353.

4. Yan, XM; Tanaka, T.; Kawaguchi, H.* Reduced pressure inductively coupled plasma mass spectrometry for nonmetallic elements, Appl. Spectrosc., 1996, 50, 182-187.

3. Wang, XR*; Zhuang, ZX; Yang, CL; Yang, PY; Yan, XM; Lin, JM. Development of transient data acquisition system for hyphenated techniques coupled with inductively coupled plasma atomic emission spectrometry, Spectrochim. Acta B, 1996, 51, 1753-1759.

2. Yan, XM; Wang, XR; Yang, PY; Hang, W; Huang, BL*. Signal Acquisition and processing in transient introduction techniques on-line hyphenated with multichannel ICP-AES, Chem. J. Chinese U., 1993, 14, 1506-1509.

1. Wang, XR*; Zhu, EY; Yan, XM; Yang, PY; Huang, BL; Zhuang, ZX. Chemometrics study on preliminary clinical diagnostics for cancer patients, Acta Chim. Sinica, 1993, 51, 1094-1098.