The Yan Laboratory focuses on the development of advanced instrumentation and methodologies for Analytical/Bioanalytical Chemistry and Chemical Biology. In particular, by integrating light scattering with techniques for single-molecule fluorescence detection in a sheathed flow, we have developed high sensitivity flow cytometry (HSFCM) that achieves real-time light scattering detection of single silica and gold nanoparticles as small as 24 nm and 7 nm in diameter, respectively. With a resolution comparable to that of TEM and the ease and speed of flow cytometric analysis, HSFCM provides quantitative physical (size, particle concentration) and biochemical characterization of single nanoparticles demanded in nanotechnology, nanobiotechnology, nanomedicine, biopharmaceuticals, and life science. The research of our group interfaces with chemistry, biological and medical sciences, materials science, and instrumentation. We always have open positions for talented and self-motivated students and post doctors.